Heart–brain interactions during social and cognitive stress in hypertensive disease: A multidimensional approach
Eur J Neurosci.
Legaz A, Yoris A, Sedeño L, Abrevaya S, Martorell M, Alifano F, García AM, Ibañez A. Heart-brain interactions during social and cognitive stress in hypertensive disease: a multidimensional approach. Eur J Neurosci. 55(9), 2836-2850, https://doi.org/10.1111/ejn.14979
La enfermedad hipertensiva, un factor de riesgo importante para las enfermedades cardiovasculares y cerebrovasculares, se caracteriza por una elevada propensión al estrés. Dado que los niveles de estrés se basan en factores cardíacos y neuronales, se requieren conocimientos multidimensionales para comprender cabalmente su perturbación en la HTD. Sin embargo, a pesar de su importancia crucial, la variabilidad de la frecuencia cardíaca y los marcadores neurocognitivos multimodales de estrés en el síndrome de estrés térmico siguen siendo controvertidos e inexplorados, respectivamente. Para salvar esta brecha, estudiamos medidas cardiodinámicas, electrofisiológicas y neuroanatómicas de estrés en pacientes con HTD y controles sanos. Ambos grupos realizaron la Prueba de Estrés Social de Trier (TSST), una tarea validada de inducción de estrés que comprende una línea de base y un período de estrés mental. Durante ambas etapas, evaluamos un parámetro sensible de VRH (la relación baja frecuencia/alta frecuencia [LF/HF]) y una medida neurofisiológica en línea (el potencial evocado por los latidos del corazón [HEP]). También obtuvimos datos neuroanatómicos mediante morfometría basada en vóxeles (VBM) para la correlación con los marcadores en línea.
Heart–brain interactions during social and cognitive stress in hypertensive disease: A multidimensional approach
Eur J Neurosci.
Legaz A, Yoris A, Sedeño L, Abrevaya S, Martorell M, Alifano F, García AM, Ibañez A. Heart-brain interactions during social and cognitive stress in hypertensive disease: a multidimensional approach. Eur J Neurosci. 55(9), 2836-2850, https://doi.org/10.1111/ejn.14979
Hypertensive disease (HTD), a prominent risk factor for cardiovascular and cerebrovascular diseases, is characterized by elevated stress‐proneness. Since stress levels are underpinned by both cardiac and neural factors, multidimensional insights are required to robustly understand their disruption in HTD. Yet, despite their crucial relevance, heart rate variability (HRV) and multimodal neurocognitive markers of stress in HTD remain controversial and unexplored respectively. To bridge this gap, we studied cardiodynamic as well as electrophysiological and neuroanatomical measures of stress in HTD patients and healthy controls. Both groups performed the Trier Social Stress Test (TSST), a validated stress‐inducing task comprising a baseline and a mental stress period. During both stages, we assessed a sensitive HRV parameter (the low frequency/high frequency [LF/HF ratio]) and an online neurophysiological measure (the heartbeat‐evoked potential [HEP]). Also, we obtained neuroanatomical data via voxel‐based morphometry (VBM) for correlation with online markers. Relative to controls, HTD patients exhibited increased LF/HF ratio and greater HEP modulations during baseline, reduced changes between baseline and stress periods, and lack of significant stress‐related HRV modulations associated with the grey matter volume of putative
